Malvern Instruments is pleased to announce two webinars for March 2017; the first will be an exploration of the potential applications of differential scanning calorimetry in protein characterisation, while the second will discuss the benefits of integrating particle size analysis in cement plant operations.
Differential scanning calorimetry: precise, in-depth characterisation of therapeutic protein stability
Differential scanning calorimetry (DSC) is a meticulous and powerful process used for characterising the thermal stability of proteins.
During the life history of a commercial therapeutic protein product, DSC analysis is uniquely valuable from early discovery research to commercial product management.
Areas where DSC methodology could be used include: comparing stability of potential drug candidates, conducting preformulation and formulation screening studies, biophysical characterization of drug product for regulatory filings and comparability studies after a manufacturing change, as well as comparing a biosimilar to an innovator drug product.
DSC analysis of a protein can also provide insightful data in investigations of the roles of specific domains in the instability and aggregation of multi-domain proteins.
In this webinar, some examples of these applications will be described.
In addition, results from studies on the effects of heating rate will presented, which demonstrate that faster heating results in both increased sample throughput and increased method sensitivity.
Finally, data will be presented from a recent biophysical comparison of antibody drug conjugates to the parent antibody.
These results documented that important differences in thermal stability could readily be resolved and quantified with DSC, whereas during heating studies with various spectroscopic techniques no differences were discernable.
Summary
- Measurement type: Microcalorimetry
- Date: 14 March 2017
- Time: 10:30-11:30 (GMT-05:00) Eastern [US & Canada]
- Event type: Webinar – Live
- Language: English
Cement: composition, structure and fineness
Global demand for cement production continues to grow, and analysts predict that the industry will maintain a healthy expansion rate well into the next decade.
This positive outlook translates into mounting pressures on the manufacturers to increase throughput of new and existing plants, while at the same time striving to reduce the environmental impact of cement manufacture though process optimization and use of clinker substitutes.
This presentation will review the importance of elemental and mineralogical analysis and the value of precise analytical data to plant operations.
We will also discuss the importance of cement fineness and how precision and timeliness aspects of particle size analysis are related to production control and efforts to optimize grinding and reduce energy consumption.
Summary
- Measurement type: Particle size
- Date: 22 March 2017
- Time: 15:00-16:00 (GMT)
- Event type: Webinar – Live
- Language: English
