The self-association characteristics of molecules in dilute solutions can provide an assessment of stability at an early stage in development. The diffusion interaction parameter (kD) is a measure of the propensity for self-association, but the determination of this parameter using existing methodologies requires several measurements over a concentration series.
Here, we show how Taylor Dispersion Analysis can be used to generate a concentration gradient from which the kD can be extracted in a single, low volume measurement, making this an excellent choice of technology for early stability assessment, particularly for biopharmaceuticals.
- Measurement type: Particle size, Protein stability
- Date: 15 November 2016
- Time: 10:30 – 11:30 (GMT-05:00) Eastern [US & Canada]
- Event type: Webinar – Live
- Language: English